Gemfibrozil as a potential heme-independent sGC activator
نویسندگان
چکیده
Background Cyclic GMP producing soluble guanylyl cyclase (sGC) is highly activated by the binding of nitric oxide (NO) messenger to its heme. Besides NO, other NO-independent molecules were shown to activate sGC. These include a class of heme-replacers (e.g., protoporphyrin IX and structurally unrelated activators BAY 58-2667 and HMR1766) or sGC stimulators (e.g., BAY 41-2272 and YC-1 and aryl-acrylamide derivatives). The later class requires heme and sensitize sGC to low NO concentrations. Collectively these data suggest that various modes of allosteric sGC regulation are possible and some may have not been identified yet.
منابع مشابه
Mechanism of YC-1-induced activation of soluble guanylyl cyclase.
The signaling molecule nitric oxide (NO) mediates many of its effects by the stimulation of soluble guanylyl cyclase (sGC). The activation process is initiated by high-affinity binding of NO to the enzyme's prosthetic heme group. Despite its poor sGC-activating properties, carbon monoxide (CO) has also been suggested as a physiological activator of sGC. Recently, we have shown that the substanc...
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